Which of the following describes the modes of toxicity for benzene?

The correct choice identifies benzene's modes of toxicity comprehensively. Benzene is known to have several toxic effects on the body. As a carcinogen, it has been linked to various cancers, particularly leukemia, making its classification as such crucial. Its role as an irritant can affect the respiratory system and skin upon exposure, leading to adverse effects. Additionally, benzene acts as a systemic poison, which means it can disrupt the function of multiple organ systems when absorbed, leading to broader health issues.

This holistic view encompasses benzene's multifaceted nature, where multiple pathways of toxicity contribute to its overall harmfulness. By addressing its depressant effects on the central nervous system, irritant properties, and its classification as a systemic poison along with its carcinogenic potential, this choice captures the necessary aspects of benzene's toxicity. Each of these factors is significant in assessing risk and implementing safety measures in occupational settings where benzene exposure may occur.